Curriculum Vitae

Appointments and employment

Education and training

Certifications

• Board certified in Internal Medicine
• Board certified in Pulmonary Disease
• Board certified in Critical Care Medicine

Research support

Current

Completed

Selected scholarly outputs

1. Large language models generate diagnostic likelihood ratios with low mean bias but wide dispersion. Chong P, He S, Samadian K, Mohamed A, Peng B, Chua E, Rohlfsen C, Locke BW. Scientific Reports. 2026. doi:10.1038/s41598-026-61766-2 PubMed
2. Exploring the Impact of Virtual Reality Interventions on Autonomic Arousal in ICU Patients. Finkelstein J, Gabriel AS, Locke BW, Tsai TY, Reategui-Rivera CM, Smiley A. Proceedings of the 2025 World Conference of the International Society for Virtual Rehabilitation. 2026. doi:10.1007/978-3-032-17790-2_39
3. AI-Based Simulated Patient Encounters for Clinical Reasoning: A Needs Assessment. Sorrick A, Liebovitz D, Vick S, Parsons AS, Locke BW, Herskovitz J, Rohlfsen C. Graduate Medical Education Research Journal. 2026. doi:10.32873/unmc.dc.gmerj.8.1.004
4. Splenectomy Increases CTEPH Risk and Modifies Clinical Features of Acute Pulmonary Embolism. White D, Locke BW, Scarpato BM, Cirulis MM, Raif K, Dodson MW. Pulmonary Circulation. 2026. doi:10.1002/pul2.70231 PubMed
5. Post-Acute Ventilator Weaning and Discharge Outcomes in Individuals With Cervical Spinal Cord Injury. Fenger C, Locke BW, Barker J, Tang W, Creveling P, Foster-Palmer S, Flis A, Park K, Rosenbluth J, Brown JP. Respiratory Care. 2026. doi:10.1177/19433654261428406 PubMed
6. The Consistency of Hypercapnic Respiratory Failure Case Definitions in Electronic Health Record Data. Locke BW, Richards WW, Gouripeddi R, Brown JP, Anderson-Bell D, Finkelstein J, Sundar KM, Peltan ID, Brown SM. CHEST. 2026. doi:10.1016/j.chest.2025.08.002 PubMed
7. Emergency Department Presenting Concerns Among Admissions With Hypercapnia: A Retrospective NLP Study of MIMIC-IV. Merdad RH, Ramirez M, Christenson M, Pettine WW, Locke BW. medRxiv. 2026. doi:10.64898/2026.07.03.26357242
8. Diagnostic Modeling to Identify Unrecognized Inpatient Hypercapnia Using Health Record Data. Locke BW, Richards WW, Brown JP, Cui W, Finkelstein J, Sundar KM, Gouripeddi R. Artificial Intelligence in Medicine / Lecture Notes in Computer Science. 2024. doi:10.1007/978-3-031-66538-7_4
9. Decision Curve Analysis for Evaluating Machine Learning Models for Next-Day Transfer Out of ICU. Pozo M, Pape A, Locke B, Pettine WW. medRxiv. 2026. doi:10.64898/2026.04.19.26351213 PubMed
10. Entropy removal of clinical features. Samadian KD, Chua E, Peng B, Coleska A, Hassan A, Chong P, Locke B, Liebovitz DM, Rohlfsen C, He S. Scientific Reports. 2025. doi:10.1038/s41598-025-29069-0 PubMed
11. The association of weight loss from anti-obesity medications or bariatric surgery and apnea-hypopnea index in obstructive sleep apnea. Locke BW, Gomez-Lumbreras A, Tan CJ, Nonthasawadsri T, Veettil SK, Patikorn C, Chaiyakunapruk N. Obesity Reviews. 2024. doi:10.1111/obr.13697 PubMed
12. Assessing Foundation Models' Transferability to Physiological Signals in Precision Medicine. Christenson M, Geary C, Locke B, Koirala P, Pettine WW. arXiv. 2024. doi:10.48550/arxiv.2412.03427
13. Immersive Virtual Reality Use in Medical Intensive Care: Mixed Methods Feasibility Study. Locke BW, Tsai TY, Reategui-Rivera CM, Gabriel AS, Smiley A, Finkelstein J. JMIR Serious Games. 2024. doi:10.2196/62842
14. Use of High-Dose Hydroxocobalamin for Septic Shock. Carr JR, Locke B, Patel JJ, Peltan ID, Brown SM, Bosch NA, Law AC. CHEST. 2025. doi:10.1016/j.chest.2025.01.016 PubMed
15. Surgical and N95 Masks in Chronic Hypercapnic Respiratory Failure: What Physiology Can and Cannot Tell Us. Locke BW. Respiratory Care. 2026. doi:10.1177/19433654261424871 PubMed
16. The Role of Obstructive Sleep Apnea in Hypercapnic Respiratory Failure Identified in Critical Care, Inpatient, and Outpatient Settings. Locke BW, Brown JP, Sundar KM. Sleep Medicine Clinics. 2024. doi:10.1016/j.jsmc.2024.02.012
17. Seeing the random forest for the Zzz's: machine learning's new role in sleep science. Anderson-Bell D, Locke BW. Journal of Clinical Sleep Medicine. 2025. doi:10.5664/jcsm.11674 PubMed
18. OSA and Chronic Respiratory Disease: Mechanisms and Epidemiology. Locke BW, Lee JJ, Sundar KM. International Journal of Environmental Research and Public Health. 2022. doi:10.3390/ijerph19095473
19. Hickam's Dictum: An Analysis of Multiple Diagnoses. Aberegg SK, Poole BR, Locke BW. Journal of General Internal Medicine. 2024. doi:10.1007/s11606-024-09120-y
20. What Are We Aiming for in Chronic Hypercapnic Respiratory Failure? Locke BW, Brown J. Respiratory Care. 2023. doi:10.4187/respcare.11573
21. Uncomfortable Truths About Data, Justice, and Idiopathic Pulmonary Fibrosis in the Veterans Health Administration. Locke BW, Callahan SJ. CHEST. 2023. doi:10.1016/j.chest.2023.03.037

Selected presentations

Teaching and curriculum

Service, honors, and peer review

Service

• Core Faculty, University of Utah Pulmonary and Critical Care Fellowship
• Investigator, University of Utah Medical Machine Intelligence Lab
• Program Committee, 22nd International Conference on Artificial Intelligence in Medicine
• University of Utah School of Medicine Phase IV Subcommittee
• University of Utah Student Trainee Advisory Committee, member and chair
• University of Utah GME Value Council, founding member

Honors

Peer review

• American Journal of Respiratory and Critical Care Medicine
• Respiratory Care
• Journal of Clinical Sleep Medicine
• Journal of Medical Internet Research
• International Journal of Environmental Research and Public Health
• Sleep and Breathing
• Sleep Epidemiology
• Lung

Professional disclosure

Brian W. Locke has an equity interest in and serves as an advisor to Mountain Biometrics, Inc. (MTN), a healthcare data-integration company. This relationship is separate from his role at Intermountain Health.