Curriculum Vitae
Brian W. Locke, MD, MSCI
Assistant Professor of Research, Intermountain Health
Pulmonary and Critical Care Physician
Advisor, MTN · Adaptive healthcare data integration
A compact public academic CV. Complete publication records are available through Google Scholar and ORCID.
Appointments and employment
2024–present
Assistant Professor of Research
Intermountain Health
2024–present
Pulmonary and Critical Care Physician
Shock Trauma ICU and Schmidt Chest Clinic, Intermountain Health
2024–present
Advisor
Mountain Biometrics, Inc. (MTN)
2025–present
Core Faculty
University of Utah Pulmonary and Critical Care Fellowship
2025–present
Adjunct Faculty
Department of Medical Education, University of Utah
Education and training
2005–2009
B.S. in Computer Science
University of Colorado, Boulder
Honors thesis: Named Entity Recognition: Adapting to Microblogging
2010–2012
M.S. in Health Sciences
Montana State University
Thesis: The Effect of Boot Stiffness on Collegiate Alpine Ski Racers
2012–2016
M.D.
University of Colorado School of Medicine
2021–2023
M.S. in Clinical Investigation
University of Utah
2016–2019
Internal Medicine Resident
University of Utah Affiliated Hospitals
2019–2020
Chief Medical Resident, Internal Medicine
University of Utah Affiliated Hospitals
2020–2023
Pulmonary and Critical Care Medicine Fellow
University of Utah Affiliated Hospitals
2022–2024
T32-Sponsored Research Fellow
University of Utah
Certifications
- Board certified in Internal Medicine
- Board certified in Pulmonary Disease
- Board certified in Critical Care Medicine
Research support
Current
11/2025–06/2027
Informing best practices for evaluation and treatment of myocardial injury during sepsis
Evaluates diagnostic and treatment practices for myocardial injury during sepsis using harmonized electronic health record data.
09/2024–02/2027
Follow-up Utilization and Needs after Discharge with Hypercapnic Respiratory Failure (FUND-Hypercapnia)
Uses administrative data to characterize post-discharge testing, specialty referral patterns, healthcare utilization, and costs after hospitalization with hypercapnic respiratory failure.
Completed
07/2022–06/2024
Developing a Computable Phenotype for Hypercapnic Respiratory Failure
Supported development of reproducible electronic health record approaches to defining hypercapnic respiratory failure.
06/2022–05/2024
Multidisciplinary Pulmonary and Critical Care Research Training Program
Supported formal research training in pulmonary and critical care clinical investigation.
Selected scholarly outputs
- Post-Acute Ventilator Weaning and Discharge Outcomes in Individuals With Cervical Spinal Cord Injury. Fenger C, Locke BW, Barker J, Tang W, Creveling P, Foster-Palmer S, Flis A, Park K, Rosenbluth J, Brown JP. Respiratory Care. 2026. doi:10.1177/19433654261428406
- The Consistency of Hypercapnic Respiratory Failure Case Definitions in Electronic Health Record Data. Locke BW et al. CHEST. 2025. doi:10.1016/j.chest.2025.08.002
- Emergency Department Presenting Concerns Among Admissions With Hypercapnia: A Retrospective NLP Study of MIMIC-IV. Merdad R, Ramirez M, Christenson M, Pettine WW, Locke BW. medRxiv. 2026. doi:10.64898/2026.07.03.26357242
- Diagnostic Modeling to Identify Unrecognized Inpatient Hypercapnia Using Health Records. Locke BW et al. Artificial Intelligence in Medicine / Lecture Notes in Computer Science. 2024. doi:10.1007/978-3-031-66538-7_4
- Decision Curve Analysis for Evaluating Machine Learning Models for Next-Day Transfer Out of ICU. Pozo M, Pape A, Locke B, Pettine WW. medRxiv. 2026. doi:10.64898/2026.04.19.26351213
- The association of weight loss from anti-obesity medications or bariatric surgery and apnea-hypopnea index in obstructive sleep apnea. Locke BW et al. Obesity Reviews. 2024. doi:10.1111/obr.13697
- Immersive Virtual Reality Use in Medical Intensive Care: Mixed Methods Feasibility Study. Locke BW et al. JMIR Serious Games. 2024. doi:10.2196/62842
- Surgical and N95 Masks in Chronic Hypercapnic Respiratory Failure: What Physiology Can and Cannot Tell Us. Locke BW. Respiratory Care. 2026. doi:10.1177/19433654261424871
- The Role of Obstructive Sleep Apnea in Hypercapnic Respiratory Failure Identified in Critical Care, Emergency, Inpatient, and Outpatient Settings. Locke BW, Brown JP, Sundar KM. Sleep Medicine Clinics. 2024. doi:10.1016/j.jsmc.2024.02.012
- OSA and Chronic Respiratory Disease: Mechanisms and Epidemiology. Locke BW, Lee JJ, Sundar KM. International Journal of Environmental Research and Public Health. 2022. doi:10.3390/ijerph19095473
- Hickam's Dictum: An Analysis of Multiple Diagnoses. Aberegg SK, Poole BR, Locke BW. Journal of General Internal Medicine. 2024. doi:10.1007/s11606-024-09120-y
- What Are We Aiming for in Chronic Hypercapnic Respiratory Failure?. Locke BW, Brown J. Respiratory Care. 2024. doi:10.4187/respcare.11573
- Uncomfortable Truths About Data, Justice, and Idiopathic Pulmonary Fibrosis in the Veterans Health Administration. Locke BW, Callahan SJ. CHEST. 2023. doi:10.1016/j.chest.2023.03.037
Selected presentations
2025
Simulation suggests transcutaneous CO2 sensors may accurately detect hypercapnia across settings
CHEST, Chicago, IL
2025
Rates of diagnostic evaluation for causes of hypercapnic respiratory failure in Utah
American Thoracic Society International Conference, San Francisco, CA
2025
Central versus peripheral location of pulmonary embolism in asplenic patients
American Thoracic Society International Conference, San Francisco, CA
2025
Enhancing intern leadership of inpatient emergencies
American Thoracic Society International Conference, San Francisco, CA
2025
In silico estimation of transcutaneous CO2 sensor performance
American Thoracic Society International Conference, San Francisco, CA
2024
Hypercapnic respiratory failure is infrequently reported as an adverse event in clinical trials
CHEST, Boston, MA
2024
Low research-burden study of immersive virtual reality feasibility in ICU
CHEST, Boston, MA
2024
Determinants of serum bicarbonate performance for identifying hypercapnia
American Thoracic Society International Conference, San Diego, CA
Teaching and curriculum
2026
Obesity-related respiratory failure
Invited talk · Utah American College of Physicians
2025
Recent pancreatitis evidence
Seminar · Intermountain TeleCritical Care
2025
Data Wrangling
Guest lecture · University of Utah DBMI 6016
2025
Systematic Reviews and Meta-analysis
Guest lecture · University of Utah MDCRC 6200
2025
Statistical Methods in Sleep Medicine for Establishing Causality
Invited teaching · University of Utah Sleep Division
2024–2026
Pulmonary and critical care fellowship bootcamp
Fellowship teaching · University of Utah PCCM Fellowship
2025–present
PCCM fellows journal club and statistics workshop
Curricular design · University of Utah PCCM Fellowship
2025–2026
Code blues and rapid responses
Curricular design and simulation · University of Utah Internal Medicine Residency
2024–2026
Respiratory failure and blood gas interpretation
Residency teaching · University of Utah Internal Medicine Residency
2024–2026
Clinical AI/LLMs, spirometry, and COPD
Residency teaching · University of Utah Internal Medicine Residency
Service, honors, and peer review
Service
- Core Faculty, University of Utah Pulmonary and Critical Care Fellowship
- Investigator, University of Utah Medical Machine Intelligence Lab
- Program Committee, 22nd International Conference on Artificial Intelligence in Medicine
- University of Utah School of Medicine Phase IV Subcommittee
- University of Utah Student Trainee Advisory Committee, member and chair
- University of Utah GME Value Council, founding member
Honors
2022–2024
American Thoracic Society ASPIRE Fellowship
2022 and 2023
American Thoracic Society Assembly Sleep and Respiratory Neurobiology Abstract Scholarship
2020
American Academy of Sleep Medicine Young Investigators Research Forum
2013
Top Poster, Research and Innovation, Rocky Mountain Hospital Medicine Symposium
Peer review
- American Journal of Respiratory and Critical Care Medicine
- Respiratory Care
- Journal of Clinical Sleep Medicine
- Journal of Medical Internet Research
- International Journal of Environmental Research and Public Health
- Sleep and Breathing
- Sleep Epidemiology
- Lung
Professional disclosure
Brian W. Locke has an equity interest in and serves as an advisor to Mountain Biometrics, Inc. (MTN), a healthcare data-integration company. This relationship is separate from his role at Intermountain Health.